Wolf-Hirschhorn syndrome

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a child with Wolf-Hirschhorn syndrome (46,XY,del[4p]). Note the wide-spaced eyes and repaired cleft lip.

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This is an example of 4p- in which a small part of the short arm of chromosome 4 has been lost. This is an example of a deletion. Wolf's syndrome is very rare. Affected children are small, with microcephaly and abnormal facies. There are cardiac, renal, and genital abnormalities. Most are stillborn or die in infancy.

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An infant with Wolf-Hirschhorn syndrome (4p-).  Note the wide space between the eyes.


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