Huntington's Disease


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Cross section of a brain of an adult with Huntington disease, illustrating marked striatal atrophy.

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The apparent enlargement of the ventricles seen here is due to atrophy of the head of the caudate from neuronal loss with Huntington's disease, an autosomal dominant condition characterized clinically by choreiform movements.

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Microscopically, the caudate nucleus in Huntington's disease demonstrates loss of neurons along with gliosis.

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