Hirschsprung disease

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Hirschsprung's disease results from a failure of migration of neuroblasts that form the myenteric plexus. The result is intestinal obstruction in affected neonates. The incidence is 1 per 5000 live births. Shown here is dilation of bowel (megacolon) proximal to the affected region at the lower left center in sigmoid colon. Mucosal damage and secondary infection may follow.

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